Patents Issued

Nelms, Benjamin E. “Benchmark System for Radiation Therapy Planning.” US Patent 9,463,336, filed October 11, 2013, and issued October 11, 2016. Assignee: Sun Nuclear Corp.

Nelms, Benjamin E., Kozelka, J., and Simon. W. E. “Systems and methods for composite dose quality assurance with three dimensional arrays.” US Patent 8,927,921, filed October 2, 2013, and issued January 6, 2015. Assignee: Sun Nuclear Corp.

Nelms, Benjamin E., and Simon. W. E. “Radiation therapy plan dose perturbation system and method.” US Patent 7,945,022, filed March 12, 2009, and issued May 17, 2011. Assignee: Sun Nuclear Corp.

Nelms, Benjamin E. “Dosimetry system and method for radiation therapy.” US Patent 8,130,905, filed November 20, 2008, and issued March 6, 2012. Assignee: Sun Nuclear Corp.

Nelms, Benjamin E. “Radiation therapy using beam modifiers placed against a patient’s skin.” US Patent 8,121,253, filed January 28, 2010, and issued February 21, 2012. Assignee: .decimal, Inc.

Nelms, Benjamin E., Miller, N., and Manion, J. “System for assessing radiation treatment plan segmentations.” US Patent 8,081,813, filed May 29, 2009, and issued December 20, 2011. Assignee: Standard Imaging, Inc.

Nelms, Benjamin E. “System and method for improved radiation dosimetry.” US Patent 8,173,968, filed February 17, 2011, and issued May 8, 2012. Assignee: Wisconsin Alumni Research Foundation.

Patents Pending

Nelms, Benjamin E. “Benchmark System for Radiation Therapy Planning.” US Patent Application 14/051,752, filed September 20, 2013 (provisional) and October 11, 2013 (non-provisional).

Nelms, Benjamin E. “Patient-Customized Medical Treatment Education System and Methods.” US Patent Application 12/545,962, filed August 24, 2009.

Selected Publications by Ben Nelms and Colleagues

[Ordered by publication date, most recent first]

Gintz D, Latifi K, Caudell J, Nelms B, Zhang G, Moros E, and Feygelman V. Initial evaluation of automated treatment planning software. J Appl Clin Med Phys. 2016; 17(3).

Feygelman V, Tonner B, Stambaugh C, Dylan Hunt, Zhang G, Moros E, and Nelms BE. Technical Note: Motion-perturbation method applied to dosimetry of dynamic MLC target tracking—A proof-of-concept. Med. Phys. 2015 Nov; 42(11).

Nelms BE, Stambaugh C, Hunt D, Tonner B, Zhang G, and Feygelman V. Methods, software and datasets to verify DVH calculations against analytical values: Twenty Years Late(r). Med Phys. 2015 Aug; 42(8).

Stambaugh C, Nelms BE, Wolf T, Mueller R, Geurts M, Opp D, Zhang G, Moros E, and Feygelman V. Measurement-guided volumetric dose reconstruction for helical tomotherapy. J Appl Clin Med Phys. 2015; 16(2).

Nelms, BE, Opp D, Zhang G, Moros E, and Feygelman, V. Motion as perturbation. II. Development of the method for dosimetric analysis of motion effects with fixed-gantry IMRT. Med. Phys. 2014 Jun;41(6).

Feygelman V, Stambaugh C, Opp D, Zhang G, Moros E, and Nelms, BE. Cross-validation of two commercial methods for volumetric high-resolution dose reconstruction on a phantom for non-coplanar VMAT beams. Radiother Oncol. 2014 Mar;110(3).

Nelms BE, Chan MF, Jarry G, Lemire M, Lowden J, Hampton C, and Feygelman V. Evaluating IMRT and VMAT dose accuracy: Practical examples of failure to detect systematic errors when applying a commonly used metric and action levels. Med Phys. 2013 Nov; 40(11): 111722 (15 pages).

Stambaugh C, Nelms BE, Dilling T, Stevens C, Latifi K, Zhang G, Moros E, Feygelman V. Experimentally studied dynamic dose interplay does not meaningfully affect target dose in VMAT SBRT lung treatments. Med Phys. 2013 Sep;40(9); 091710 (8 pages).

Zhen H, Nelms BE, Tomé WA. On the use of biomathematical models in patient-specific IMRT dose QA. Med Phys. 2013 June;40(7): 071702 (10 pages).

Opp D, Nelms BE, Zhang G, Stevens C, Feygelman V. Validation of measurement-guided 3D VMAT dose reconstruction on a heterogeneous anthropomorphic phantom. J Appl Clin Med Phys. 2013 Jul;14(4): 4154 (15 pages).

Feygelman V, Stambaugh C, Zhang G, Hunt D, Opp D, Wolf TK, Nelms BE. Motion as a perturbation: Measurement-guided dose estimates to moving patient voxels during modulated arc deliveries. Med Phys. 2013 Feb;40(2): 021708 (11 pages).

Nelms BE, Robinson G, Markham J, Velasco K, Boyd S, Narayan S, Wheeler J, Sobczak M. Variation in external beam treatment plan quality: An inter-institutional study of planners and planning systems. Practical Radiation Oncology 2012 Oct;2(4):296-305.

Nelms BE, Opp D, Robinson J, Wolf TK, Zhang G, Moros E, Feygelman V. VMAT QA:  measurement-guided 4D dose reconstruction on a patient. Med Phys. 2012 Jul;39(7):4228-38.

Nelms BE, Tomé WA, Robinson G, Wheeler J. Variations in the contouring of organs at risk: test case from a patient with oropharyngeal cancer. Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):368-78.

Bailey DW, Nelms BE, Attwood K, Kumaraswamy L, Podgorsak MB. Statistical variability and confidence intervals for planar dose QA pass rates. Med Phys. 2011 Nov;38(11):6053-64.

Zhen H, Nelms BE, Tome WA. Moving from gamma passing rates to patient DVH-based QA metrics in pretreatment dose QA. Med Phys. 2011 Oct;38(10):5477-89.

Kozelka J, Robinson J, Nelms B, Zhang G, Savitskij D, Feygelman V. Optimizing the accuracy of a helical diode array dosimeter: a comprehensive calibration methodology coupled with a novel virtual inclinometer. Med Phys. 2011 Sep;38(9):5021-32.

Nelms BE, Zhen H, Tomé WA. Per-beam, planar IMRT QA passing rates do not predict clinically relevant patient dose errors. Med Phys. 2011 Feb;38(2):1037-44.

Feygelman V, Zhang G, Stevens C, Nelms BE. Evaluation of a new VMAT QA device, or the “X” and “O” array geometries. J Appl Clin Med Phys. 2011 Jan 31;12(2):3346.

Nelms BE, Rasmussen KH, Tome WA. Evaluation of a fast method of EPID-based dosimetry for intensity-modulated radiation therapy. J Appl Clin Med Phys. 2010 Apr 19;11(2):140-157.

Nelms BE, Ehler E, Bragg H, Tomé WA. Quality assurance device for four-dimensional IMRT or SBRT and respiratory gating using patient-specific intrafraction motion kernels.J Appl Clin Med Phys. 2007 Sep 17;8(4):2683.

Nelms BE, Simon JA. A survey on planar IMRT QA analysis. J Appl Clin Med Phys. 2007 Jul 17;8(3):2448.

Ehler ED, Nelms BE, Tomé WA. On the dose to a moving target while employing different IMRT delivery mechanisms. Radiother Oncol. 2007 Apr;83(1):49-56. Epub 2007 Mar 9.

Black RD, Scarantino CW, Mann GG, Anscher MS, Ornitz RD, Nelms BE. An analysis of an implantable dosimeter system for external beam therapy. Int J Radiat Oncol Biol Phys. 2005 Sep 1;63(1):290-300.

Jursinic PA, Nelms BE. A 2-D diode array and analysis software for verification of intensity modulated radiation therapy delivery. Med Phys. 2003 May;30(5):870-9.

Gould MN, Nelms BE, Hill CK, Mackay JF, Lindstrom MJ, Mackie TR, Deluca PM Jr. Radiobiological studies using synchrotron-produced ultrasoft X-rays. J Radiat Res. 1999 Dec;40 Suppl:66-73. PubMed PMID: 10804996.

Nelms BE, Mackie TR, MacKay JF, Hill CK, DeLuca PM Jr, Lindstrom MJ, Deasy J, Gould MN. A comparison of cytotoxicity after whole- or partial-cell irradiation with synchrotron-produced ultrasoft X rays. Radiat Res. 1998 Nov;150(5):521-7.

Hill CK, Nelms BE, MacKay JF, Pearson DW, Kennan WS, Mackie TR, DeLuca PM Jr, Lindstrom MJ, Gould MN. Synchroton-produced ultrasoft X rays: equivalent cell survival at the isoattenuating energies 273 eV and 860 eV. Radiat Res. 1998 Nov;150(5):513-20.

Bressan DA, Olivares HA, Nelms BE, Petrini JH. Alteration of N-terminal phosphoesterase signature motifs inactivates Saccharomyces cerevisiae Mre11. Genetics. 1998 Oct;150(2):591-600.

MacKay JF, Pearson DW, Nelms BE, DeLuca PM Jr, Gould MN, Lagally MG. A double mirror W/C multilayer monochromator for radiation biology applications. Med Phys. 1998 May;25(5):773-9.

Nelms BE, Maser RS, MacKay JF, Lagally MG, Petrini JH. In situ visualization  of DNA double-strand break repair in human fibroblasts. Science. 1998 Apr 24;280(5363):590-2.

Maser RS, Monsen KJ, Nelms BE, Petrini JH. hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Mol Cell Biol. 1997 Oct;17(10):6087-96.

 

DNA-DSB-and-Repair-Post-SoftXray

Figure 1. Towards the end of graduate school at the Univ. of Wisconsin, I was fortunate enough to cross paths with Dr. John Petrini and his talented Genetics lab members. Using our radiobiology-dedicated synchrotron beamline and some special software tools I had developed, I was able to help them publish three seminal papers in the field of DNA repair post-irradiation, including our 1998 paper in Science. Pictured here is one of the exciting figures from that paper, showing co-localization of DNA double-strand breaks and their associated repair after irradiation with spatially “striped” soft x-rays. (Note: John Petrini is now the Director of The Functional Genomics Initiative at Memorial Sloan-Kettering.)